Which organ is primarily responsible for producing fibrinogen?

Which organ is primarily responsible for producing fibrinogen?

• A. Pancreas
• B. Liver
• C. Spleen
• D. Bone marrow

Answer: (B)

Fibrinogen is a soluble plasma glycoprotein produced primarily by the liver, where hepatocytes secrete it into the bloodstream to participate in clot formation. In the coagulation cascade, thrombin converts fibrinogen into fibrin to form the clot. The other organs listed do not produce fibrinogen: the pancreas makes digestive enzymes, the spleen mainly filters blood and supports immune function, and the bone marrow generates blood cells. While fibrinogen levels can rise during inflammation as an acute-phase reactant, its main source under normal conditions is the liver.

Fibrinogen is a soluble plasma glycoprotein produced primarily by the liver, where hepatocytes secrete it into the bloodstream to participate in clot formation. In the coagulation cascade, thrombin converts fibrinogen into fibrin to form the clot. The other organs listed do not produce fibrinogen: the pancreas makes digestive enzymes, the spleen mainly filters blood and supports immune function, and the bone marrow generates blood cells. While fibrinogen levels can rise during inflammation as an acute-phase reactant, its main source under normal conditions is the liver.